Time will tell: Decision making in premanifest and manifest Huntington’s disease

MRI Tz Hypointensities in basal ganglia of premanifest Huntingtons disease

Magnetization transfer imaging in premanifest and manifest Huntington disease.

BACKGROUND AND PURPOSE MTI has the potential to detect abnormalities in normal-appearing white and gray matter on conventional MR imaging. Early detection methods and disease progression markers are needed in HD research. Therefore, we investigated MTI parameters and their clinical correlates in premanifest and manifest HD. MATERIALS AND METHODS From the Leiden TRACK-HD study, 78 participants...

Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington’s Disease

BACKGROUND We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease. METHODS Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left an...

Neural Correlates and Progression of Saccade Impairment in Premanifest and Manifest Huntington Disease

Cognition in Huntington's disease in manifest, premanifest and converting gene carriers over ten years.

BACKGROUND Cognitive decline in Huntington's disease (HD) remains an area of inconsistencies, especially far from disease onset. OBJECTIVE To clarify the course of cognition in premanifest HD. METHODS Twenty-six premanifest HD, 19 manifest HD, and 87 control subjects were followed for ten years, using an extensive cognitive battery. Differences in baseline levels and change over time, on fo...